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High levels of glutathione therefore allow the body to produce more white blood cells constituting the first line of defense of the immune system

In contrast, glutathione S-transferase omega 1 (GSTO1) functions as a pro-pyroptotic licensing factor by catalyzing deSSG of core inflammasome assembly components

Astrocytes in ALS show many signs of functional decline, for example they demonstrate abnormal Ca 2+ signalling, 573 impaired secretion of neuroprotective glial-derived neurotrophic factor, 574 as well as reduced lactate production

These are collectively referred to as parkinsonism (1), and they are the result of the progressive loss of dopaminergic neurons in substantia nigra (2) along with the formation of Lewy bodies that comprise misfolded -synuclein in the neurons (3)