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APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimers disease

In this issue of Plant Physiology , Speiser et al

Since H3K18la affects DNA transcriptional activity by enriching at the promoters of target genes, such as the oncogene c-Myc (20), this lactylation modification consequently confers therapy resistance by activating survival-related genes, including glutamate-cysteine ligase catalytic subunit (52)

Similar favorable results have also been reported in muscular dystrophy mice models, where sulforaphane treatment alleviated muscle inflammation in dystrophin-deficient mdx mice (Sun et al., 2015b)