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In this way, many hydrazyl permanent or stable free radicals containing carboxyl or sulfono groups are obtained from these derivatives, generally in a single step with high yield (Blois 1958)

doi: 10.3390/ijms23158194 69 SaadFHaiderAGoorenL

This reaction results in an intra-helical methylene bridge that, in turn, induces a large conformational change leading to the allosteric activation of HxIR

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