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doi: 10.3389/fnins.2021.587197 Received 25 July 2020 Accepted 10 February 2021 Published 16 March 2021 Volume 15 - 2021 Edited by Anwen Shao, Zhejiang University, China Reviewed by Yi Yang, First Affiliated Hospital of Jilin University, China

10.3233/JAD-171042 96 SorollaM

8 Conclusion Chronic stress may contribute to cognitive dysfunction in ME/CFS by disrupting HPA-axis homeostasis and adversely affecting key cognitive regions such as the hippocampus