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Rheumatology , 58 (12), 2177-2180

Maira, S.-M

However, this response may result in persistent methyl exhaustion in the event of chronic arsenic exposure leading to hypomethylation of DNA, which can alter the gene expression making the cells susceptible to carcinogenesis [6]

AGE accumulation is increasingly recognized as a contributor to oxidative stress and chronic inflammation, thereby promoting the development and progression of metabolic and vascular disease and other chronic pathologies 35,36,37,38