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Health Effects of Smoking on Your Body Decades of daily smoking cause progressive and often irreversible damage to the chest and lungs. Long term exposure to tobacco smoke leads to chronic inflammation, loss of lung elasticity, reduced oxygen exchange, and Smoking driven systemic inflammation elevates mortality risk in hypertensive patients: A cross sectional study using insights from NHANES 19992018 Smoking cessation and vascular endothelial function Hypertension Research

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