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Most people refer to B12 as cobalamin, although there are several different forms, including methylcobalamin and 5-deoxy-adenosylcobalamin (the metabolically active versions), hydroxocobalamin, and cyanocobalamin

CASTp server 52 was used for the identification of active site of the proteins

Glyoxalases, the key enzymes in the detoxification of methylglyoxal, a byproduct of glycolysis and precursor of advanced glycation end-products, are compromised by oxidation and downregulation

2.1 Mitochondrial stress and structural damage Mitochondria, as the primary organelles responsible for cellular energy metabolism, are highly sensitive to exercise-induced stress