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PYC modulated cytokine secretion by decreasing in T-helper (Th)1 cytokine levels and increasing Th2 cytokine levels and partially recovered T- and B-cell dysfunction in a mouse model ( In a murine model, PYC demonstrated neuroprotective effects following traumatic brain injury, characterized by a reduction in the proinflammatory cytokines IL-6 and TNF- (Scheff et al., 2013)

Miri, K

In contrast, non-nucleoside DNMTi with various chemical scaffolds has attracted great attention (Medina-Franco et al., 2015)

[DOI] [PMC free article] [PubMed] [Google Scholar] Quinto N.L., Rocha L.W., Silva G.F., Reichert S., Claudino V.D., Lucinda-Silva R.M., Malheiros A., De Souza M.M., Cechinel Filho V., Bell Bresolin T.M., da Silva Machado M., Wagner T.M., Meyre-Silva C