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[DOI] [PMC free article] [PubMed] [Google Scholar] 566.Gallitto M, Cheng He R, Inocencio JF, Wang H, Zhang Y, Deikus G, et al

Drop one dose level every 4 weeks (for example, from 10mg to 7.5mg to 5mg to 2.5mg)

By disrupting this process, it weakens the bacteria's defence mechanism

Importantly, proteins directed to the ER, where the synthesis, folding, and assembly of secretory and transmembrane proteins take place, play essential roles in cellular homeostasis and signaling, which are closely associated with nearly all aspects of cell physiology