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Research (154) has shown that silencing pannexin-1 can promote the expression of the intracellular antioxidant enzyme HO-1 and inhibit ferroptosis through the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway, thereby reducing ischemia-reperfusion injury in the kidneys

Moreover, most PDMS-based OoC rely on irreversible closing systems, impeding the opening of the chip before endpoint analysis, thus limiting sample accessibility and post-culture interventions (78)

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However, excessive consumption of glutamine also impedes the growth of cisplatin-resistant cells