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KPV also reduces the expression of swelling enzymes including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), which produce swelling mediators prostaglandins and nitric oxide respectively

Nat Rev Mol Cell Biol 2015;16, 393405, doi: Baar, M

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Chondrocytes expanded to population doubling level 9 (PDL9) were treated with FOXO4-DRI to remove accumulated senescent cells