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doi: 10.1016/j.heliyon.2024.e39721 261 HazekawaMHideshimaYOnoKNishinakagawaTKawakubo-YasukochiTTakatani-NakaseTet al

Supplementary Tables 112 (download XLSX Relevant to Methods (Tables 15), raw metabolomics peak areas (Tables 67) and RNA-seq (Tables 812)

Critically, integrating genomic and molecular data has uncovered fundamental mechanisms of patient heterogeneity, such as the discovery that a diurnal BMAL1-HIF2A complex regulates myocardial vulnerability to injury, providing a molecular rationale for the long-observed circadian patterns of MI severity and opening the door to chronopharmacologytiming interventions for maximum efficacy (Ruan et al., 2025)