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Here we unveiled an essential role of E3 ligase SMAD ubiquitylation regulatory factor 1 (Smurf1)-mediated phosphoinositide-dependent protein kinase 1 (PDK1) neddylation in PI3KAkt signaling and tumorigenesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Tanito M., Nakamura H., Kwon Y.-W., Teratani A., Masutani H., Shioji K., Kishimoto C., Ohira A., Horie R., Yodoi J