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ApoE / mice were exposed to saline, e-cigarettes without nicotine or e-cigarettes with 2.4% nicotine for 12 weeks using our newly developed mouse e-cigarette exposure model system that delivers nicotine to mice leading to equivalent serum cotinine levels found in human cigarette users

In summary, based on the findings reviewed above, it is evident that all components of electronic cigarette emissions, including those labeled and unlabeled, can possess the potential to alter reward-related processing and behavior