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The KEAP1 protein detects oxidative stress by going through a conformational change that prevents association with NRF2, leading to NRF2 accumulation and translocation to the nucleus, which then induces transcription through antioxidant response elements found in a broad set of genes involved in redox homeostasis and correcting oxidative damage

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Those recommendations reflect the fact that there is already significant and growing enrollment in D-SNPs, whereas other types of integrated delivery systems (such as PACE) have been characterized by limited participation