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10.1016/j.semcdb.2014.08.011 294 VancamelbekeM.VermeireS

Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications

For example, intranasal insulin has been shown to enhance memory and reduce progression of white matter hyperintensity volume over 12 months, supporting its potential as a BBB-bypass therapeutic via olfactory and trigeminal pathways (Kellar et al., 2021)

Grk6 knockdown reduces cellular insulin levels, and attenuates insulin secretion, but enhances proinsulin secretion consistent with decreased processing [138]