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In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Oxidative Haemolysis HaemBase The variable manifestations of disease in pyruvate kinase deficiency and their management Haematologica Rasburicase mechanism of action and development of hemolytic anemia and Download Scientific Diagram

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