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doi: 10.1093/biolre/ioy138 68 JonesB

doi: 10.3390/ma11071154 100 GuoD.-S.WangK.WangY.-X.LiuY

were the first to describe increased whole gut permeability in patients with alcohol abuse without significant liver disease, measured by a 24 h urinary excretion of 51 Cr-EDTA, which was confirmed by increased uptake of macromolecules (inulin, EDTA and cyanocobalamin) ex vivo in jejunal biopsies (145)

Diosmin comprises 90% of the European drug Daflon, which is one of the most studied preparations for the treatment of varicose veins and chronic venous disease (Szymanski 2016