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Figure 2 3.1 NK cells and tumor angiogenesis NK cells were initially shown to exert anti-angiogenic functions

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In continuation of non-Smad pathways, TGF-1 is reported to activate TAK-1 (TGF- activated kinase 1), which mediates the phosphorylation and activation of p38 and JNK MAPKs pathway (Shim et al., 2005)