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As with other substance use disorders, both genetic (such as mutations in the opioid receptor gene (10)) and environmental factors (such as exposure to trauma), contribute to the risk of developing opioid use disorder.(11) Ready access to prescription opioid, heroin, and fentanyl have all contributed to the current opioid epidemic

These inhibitors activate adenosine A2 receptors, which dilate glomerular efferent arteries, reduce intra-glomerular hypertension, lower GFR, and decrease proteinuria and renal oxygen consumption [101]

[Abstract]2026 Mar:352:151140

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