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Many patients achieve better results when GHK-Cu is part of a combined treatment strategy rather than used alone

24-hour urine copper if any prior serum copper value exceeded 140 g/dL or if the patient reports new gastrointestinal symptoms (nausea, upper abdominal discomfort)

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Key mechanisms of action include: Fibroblast activation Suppression of collagen-degrading enzymes Reduced inflammatory cytokines Enhanced granulation tissue formation Improved angiogenesis In ischemic wound models, injectable GHK-Cu restored fibroblast function and significantly accelerated skin repair compared to controls