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Cost and practical considerations Beyond the science, practical factors influence whether this combination makes sense for individual researchers

In summary, we investigated the role of GPX1 in protecting SGNs against oxidative stress by upregulating or inhibiting the expression of GPX1 in SGNs via the GPX1 mimic ebselen or the gpx1 knockout mouse model, and further determined the mechanistic details behind the neuroprotective effect of GPX1 in SGNs against peroxynitrite injury

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Heatmap generation Heatmap indicating transcript abundance and expression pattern was generated using the HEATMAP hierarchical clustering web tool ( The log2 fold-change values of relative expression levels (the 2 (Ct) value) were used to construct the heatmap