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SAM is also a precursor for polyamines, which are reported to be mediators of DR-longevity in Drosophila 23

Yusuf, D., Nuraida, L., Dewanti-Hariyadi, R., & Hunaefi, D

Thats why so many people take supplements for months and still feel tired or off-balance

A clinical trial involving 82 adults found that supplemental NAC (1.8g/day for 4 weeks) lowered plasma homocysteine levels.[ref] Who might this work best for