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Here, by using a data-driven explainable machine learning (ML) strategy 23 , multivariate and univariate analyses of epidemiological data and mechanistic studies in cultured cells and rodents, we sought to objectively identify variables influencing serum TMAO levels in participants of the European multicenter MetaCardis study

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In that scenario, succinate supplement could be beneficial, reestablishing directionality of the TCA cycle, supporting the electron transport chain and forcing the T cell into a more tolerant state

Its unparalleled strengths in live imaging, genetic manipulability, and scalable screening have made it an indispensable front-line platform for uncovering therapeutic mechanisms and flagging toxicological risks