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The court here framed Central Hudson as providing that states can regulate speech that is merely potentially misleading if the government (1) has a substantial state interest in regulating the speech, (2) the regulation directly and materially advances that interest, and (3) the regulation is no more extensive than necessary to serve the interest

Following exclusions of females ( n = 15,151), individuals under 18 years of age ( n = 6,051), those with missing serum cotinine data ( n = 821), and those with missing total testosterone data ( n = 82), the final sample size for this study consisted of 7,797 participants (Fig

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