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3.3 In Vitro functional CB2R activation and selectivity RG7774-mediated inhibition of forskolin-induced cAMP in recombinant CHO cells showed that, compared to the maximum efficacy of the reference agonist (CP55940), RG7774 is a potent, full agonist for recombinant human and mouse CB2R (EC 50 : 2.81 0.28 nM and 2.60 0.14 nM, respectively), with no effect on human CB1R (Figure 3A)

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The injection volumes are larger, but the precision at lower doses improves significantly