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Additionally, mitochondrial dysfunction contributes to osteoporosis by increasing ROS levels which disrupt the balance between bone formation and resorption [60,61,66,67]

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Thus, due to the nature of the original diagnostic criteria for GHD, and the reticence to consider aging a disease per se, even though disease risk, incidence and severity can be attributed at least in part to declining activity of the GH neuroendcrine axis, the criteria for determining if secretagogue therapy is indicated as an intervention in aging, are less stringent than those promulgated by Endocrine Society guidelines

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