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This is generally okay, so long as the new drug turns out to be better than, or at least as good as, the current standard of care

Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient mice

95% CI: 0.070.55

The role of defective gut barrier in CRC has also been confirmed in mucin 2-knockout ( MUC2 / ) mice in which the lack of gastrointestinal mucin resulted in spontaneous CRC development [106]