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Sci Trans Med (2010) 2(17):17ra9

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However, it was noted that the authors only deleted part of the coding sequence, the (p)ppGpp synthetase domain, leaving the (p)ppGpp hydrolase domain of Rel intact ( Recently, in various bacterial species, small alarmone synthetases (SASs) small proteins which contain only the synthetase domain have been discovered as alternative contributors to the cellular (p)ppGpp level ( M

47 Jiang and colleagues demonstrated that steatotic hepatocyte-derived extracellular vesicles (EVs) promote endothelial inflammation and facilitate atherogenesis by miR-1 delivery, KLF4 suppression and NF-B activation by exploiting apolipoprotein E ( ApoE )-deficient mice