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Pharmacological mechanisms The pharmacodynamic mechanism of benzodiazepine tolerance and dependence is probably homoeostatic down regulation of gamma-aminobutyric acid and benzodiazepine receptors in the limbic system.(28) Once this has occurred, withdrawal of the drug results in a state of underactivity of pathways utilising gamma-aminobutyric acid with a pattern of unapposed neuronal excitation characteristic of benzodiazepine withdrawal(29) and anxiety states.(10) Similar brain mechanisms mediate the psychological and somatic symptoms of both conditions, which are in many respects inseparable

[31] Cigarette Taxes: Issues and Options. Institute on Taxation and Economic Policy

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Your cardiovascular system is affected by two chemicals, nicotine and carbon monoxide