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Cigarette smoking effects on health in the population are overwhelming, with more than 40 million American adults smoking cigarettes, despite the many and varied warnings about how smoking kills- despite mandated health warnings stamped on every box and carton of cigarettes sold in the US

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With respect to PBECs from ex-smoking COPD patients, we only observed an increase in complex VF1, but not complex II and III, in line with the finding that the levels of complex II and complex III returned back to baseline levels upon CSE depletion in BEAS-2B cells