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A single puff of tobacco smoke contains more than 4000 chemicals Most of these chemicals prevent the body from functioning the way it should Between 43-80 these chemicals cause cancer In the United States, more than 400,000 people die each year because of smoke-related illnesses

In Natsume's Book of Friends Hinoe blows smoke in Natsume's face while talking to him on several occasions causing him to cough

Although vaping is 95% safer than smoking , according to Public Health England in 2018, e-liquids can contain a high concentration of nicotine which acts as a stimulant, similar to caffeine

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