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Among such obligations, WTO members generally must ensure that a regulation is not more trade-restrictive than necessary to fulfill a legitimate objective, for example, protecting human health and safety.[4] Assessing whether a regulation meets the WTO requirements involves an analysis of three factors: the degree to which the law and regulation, (i.e., in this case, plain packaging) contributes to a legitimate objective

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Together, they can damage blood vessels over time and cant be reversed

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