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Other substances in the air can also cause irritation that increases the risk of COPD, heavy metal dust and fumes, such as from lead or cadmium welding fumes disinfectants and cleaning chemicals pesticides, insecticides, and herbicides arsenic chemicals known as isocyanates, which are in polyurethane polycyclic aromatic hydrocarbons dust, such as from: grain and flour silica coal People are often exposed to these substances at work or in industrial areas