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Through the randomized clinical trial of healthy never-smokers over a month, we found that an increase in urinary propylene glycol, a marker of inhalation-e-cig intake, was significantly correlated with increased inflammatory response in the lung. Shields said, But it is still unknown what role, if any, nicotine containing e-cigs are involved in the patients with severe respiratory illness

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A subset of participants reported experiencing minor withdrawal symptoms, such as irritability and fatigue