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The answer lies with a single molecule: nicotine

Due to variations in ecological conditions, genetic factors, and agricultural and collection practices, quality control of herbal raw materials is still challenging (GACP)

Here's a summary of what I found during my brief research: Major Tobacco Manufacturers had discovered around the early 1960s that polonium - a radioactive substance - was part of tobacco and tobacco smoke, but failed to remove it from their products and suppressed their research to avoid the public eye - read more here

They need to be: Specific Measurable Achievable Realistic and Time-specific When making your action plan for cutting off cannabis gradually, make sure that you consider all of these aspects