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German scientists had shown in the 1930s that cigarette smoking caused lung cancer, and the Nazi government had run major antismoking campaigns

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This is a step-down therapy. Judith Prochaska, a professor at the Department of Medicine at Stanford University, licensed clinical psychologist and former president of public health nonprofit Society for Research on Nicotine and Tobacco, says the arduous FDA approval process for NRTs combined with a constant flow of novel nicotine products from Big Tobacco makes it difficult for companies like Qnovia to be successful