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The study, commissioned by the Department of Health, draws on the latest data from the British Doctors Study, which began in 1951 as one of the worlds first large studies into the effects of smoking, and the Million Women Study, which has tracked womens health since 1996

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Participants were ineligible if they were already using smoking cessation pharmacotherapy, had an unstable medical or psychiatric condition (past 30-day medical or psychiatric hospitalization prior to enrollment), were experiencing psychotic symptoms, had past-month suicidal ideation or past-year suicide attempt, or were pregnant