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The study involves a three-month program where e-cigarettes will be used to reduce participants smoking-related respiratory symptoms like shortness of breath, cough, phlegm, and mouth irritation through reduced smoking of tobacco cigarettes

A 2018 literature review of 31 studies in the peer-reviewed journal Tobacco Control found: Compared with cigarettes, HnB delivered up to 83% of nicotine and reduced levels of harmful and potentially harmful toxicants by at least 62% and particulate matter by at least 75%. Alex Clark, CEO of the Consumer Advocates for Smoke-Free Alternatives Association (CASAA), a nonprofit which champions tobacco harm reduction efforts, told Filter : CASAA supports the FDAs decision to approve IQOS for market in the United States

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