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This work was financially supported by National Science Centre in Poland under the Project No

In fact, the distal segment of the large intestine can be affected mainly by the circulating components, where both CO and nicotine could modulate the inflammatory profile and leukocyte migration, and the immunomodulatory role would prevail over the impact on the mucosa (Figure 2)

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It can also be transmitted from mother to child during pregnancy and childbirth