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If the kynurenine induction or promotion of IL-10 expression is specifically exerted on B cells, the overall relationship between the two compounds will depend on the relative involvement of T cells, B cells and probably other leukocyte populations, as stated earlier

Severe encephalopathy associated to pyruvate dehydrogenase mutations and unbalanced coenzyme Q10 content

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First, when cells were incubated with non-responsive P-Mn/TI@mHSA-N, prepared with the non-cleavable linker, a significantly reduced uptake by macrophages was observed due to the large size of the cross-linked platelet-protein system (Fig