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For example, sea cucumber-derived peptides significantly downregulated amino acids such as N-acetyl-L-histidine, L-threonine, L-alanine, and glycine in fibrotic models, suggesting their potential role in metabolic remodeling and fibrosis resolution [163]

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Geraldes and King [48] conducted a comprehensive review highlighting that elevated blood glucose levels and DM lead to vascular DAG accumulation, which activates PKC signaling pathways