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ADHD is defined a postponement in the age at which the period of increased development during childhood begins, The period of cortical thinning that occurs during adolescence partially replaces the state of cortical thickness [87] Peak cortical thickness in the cerebrum is acquired at around 7 years in regularly developing children, but at roughly 10 years in children with ADHD, with the delay most noticeable in the lateral prefrontal cortex [88]

Results In adjusted within-individual comparisons, relative to periods in which they did not receive ADHD medication, male patients had 35% lower odds of concurrent substance-related events when receiving medication (odds ratio [OR] = 0.65, 95% CI, 0.64-0.67), and female patients had 31% lower odds of concurrent substance-related events (OR = 0.69, 95% CI, 0.67-0.71)

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