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A variety of stressors in early life can cause enduring abnormalities in brain organization and structure as well as endocrine regulatory processes that lead to reduce immune competence and higher or less regulated cortisol levels, among other consequences

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Gastrointestinal disorders and surgeries Some GI-related conditions and surgeries may affect B12 absorption: Crohns disease: A chronic inflammatory disease, Crohns affects the small and large intestine particularly the distal ileum, which is where B12 is absorbed