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Nanoscale surveillance of the brain by microglia via cAMP-regulated filopodia

Neuronal injury subsequent to cerebral ischemia plays a pivotal role in the progression of ischemic brain damage, with its underlying mechanisms encompassing a spectrum of interconnected processes, including energy metabolism failure, excitotoxicity mediated by amino acid neurotransmitters, intracellular calcium overload, oxidative stress, and the activation of apoptotic signaling cascades