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Description

Often drug delivery in the colon is hampered by several gastrointestinal (GIT) disorders

(PubMed) Graf WD, Oleinik OE, Glauser TA, Maertens P, Eder DN, Pippenger CE

With the progression to the decompensated stage, the gut microbiota changes progressively in the direction of more serious disorders, and conversely, the gut microbiota dysbiosis will also break the balance state of enterohepatic circulation, affect the occurrence and development of liver diseases, and become an important driving factor for complications such as hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP) (Trebicka et al., 2021)