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While the exact causes of Crohns disease are unknown, the NIDDK notes that several factors may lead to its development, including: An autoimmune reaction caused by digestive tract bacteria Genetics, particularly if you have a sibling or parent with the condition A history of smoking, which may double your risk A high-fat diet Taking nonsteroidal anti-inflammatory drugs (NSAIDs) Even though both men and women experience the common symptoms of Crohns disease like diarrhea, stomach pain, weight loss and blood in the stool Temple Health notes that certain symptoms can show up more in one sex than the other