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Initiation injections (cabotegravir 600 mg/3 mL and rilpivirine 900 mg/3 mL) should be administered on the last day of oral lead-in, if used Every-2-month dosing schedule 2 IM injections at separate gluteal sites (opposite sides or at least 2 cm apart) during same visit Initiate injections on the last day of current antiretroviral therapy or oral lead-in, if used

doi: 10.1007/BF02088582

Prokinetic agents like metoclopramide can help by speeding up gastric emptying, directly counteracting the semaglutide-induced delay

Furthermore, the expansion of pathobionts like Peptostreptococcus can generate detrimental metabolites (e.g., indole derivatives), which directly upregulate cartilage-degrading MMP-13 (2628)