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Table 2 presents the results of univariable Mendelian randomization, demonstrating that the odds ratio (OR) of irritability for bipolar disorder was 3.13 (95% CI: 1.237.93

Systems toxicology investigations indicated that nicotine exposure also affected metabolic pathways the in liver, including upregulation of fatty acid beta-oxidation, cholesterol synthesis, gluconeogenesis, and ketone body formation pathways