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and in those who previously used nicotine replacements, the active drugs led to signi cantly better results than did placebo.124 However, in one prospective study, treating smokers who have not been successful with nicotine replacement agents with bupropion did not show signi cant increases in e cacy compared with placebo,116 nor did treating smokers who were not successful with bupropion with a NRT.118 Perhaps the di erences in these ndings can be accounted for partly because of di erences in participant recruitmentsmokers who failed abstinence in a previous clinical trial versus smokers with and without a history of prior drug use who are entering a new clinical trial

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Given that tobacco use remains a leading cause of preventable cancer deaths around the world 19 , addressing tobacco use internationally is a priority for cancer research and control communities